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Walter Brennan

Sam Blake

Gary Cooper

Henry Louis 'Lou' Gehrig

Clancy Cooper

Motorcycle Cop #1 (uncredited)

Teresa Wright

Eleanor Twitchell

Frank Faylen

Yankee Third Base Coach (uncredited)

Dan Duryea

Hank Hanneman

Ludwig Stössel

Henry 'Pop' Gehrig

Dane Clark

Fraternity Boy (uncredited)

Mary Gordon

Maid (uncredited)

Lane Chandler

Mark - Player in Locker Room (uncredited)

Ernie Adams

Miller Huggins

Hardie Albright

Van Tuyl

James Westerfield

Spectator (uncredited)

Addison Richards

Coach

Edward Peil Sr.

Policeman (uncredited)

Howard M. Mitchell

Sportsman at Ballgame (uncredited)

John Kellogg

Fraternity Boy (uncredited)

Lester Dorr

Disappointed Fan #1 (uncredited)

Spencer Charters

Mr. Larsen (uncredited)

Emory Parnell

Chicago Policeman O'Doul (uncredited)

Colin Kenny

Yankee Player on Train (uncredited)

Eddy Chandler

Motorcycle Cop #2 (uncredited)

Harry Harvey

Joe McCarthy

Hooper Atchley

Lathered Man in Barber Shop (uncredited)

Pat Flaherty

Yankee Ballplayer (uncredited)

Rex Lease

Spectator (uncredited)

George Lessey

Mayor of New Rochelle

Garry Owen

Scorecard Vendor (uncredited)

Dorothy Vernon

Family Friend (uncredited)

Cyril Ring

Photographer (uncredited)

John Ince

Man in Box Seat (uncredited)

Sarah Padden

Mrs. Roberts (uncredited)

Tom Neal

Fraternity Boy (uncredited)

Pierre Watkin

Mr. Twitchell

C. Montague Shaw

Mr. Worthington (uncredited)

John Daheim

Reporter in Hospital (uncredited)

Donald Kerr

Photographer (uncredited)

Earle Hodgins

Bottle Game Operator (uncredited)

Charles Williams

Little Strength Machine Contestant (uncredited)

Harry Hayden

Department Store Manager (uncredited)

Vinton Hayworth

Fraternity Boy (uncredited)

Wilbur Mack

Man Outside Yankee Stadium (uncredited)

Charles Cane

Plumber (uncredited)

Edgar Barrier

Hospital Doctor

Don Brodie

Girl Show Barker (uncredited)

Ben Taggart

Conductor (uncredited)

Lynton Brent

Photographer in Hospital (uncredited)

Guy Wilkerson

Sportsman at Ballgame (uncredited)

Dorothy Vaughan

Eleanor's Landlady (uncredited)

Matt McHugh

Strength Machine Operator (uncredited)

Heinie Conklin

Wallpaper Hanger (uncredited)

Edward Fielding

Clinic Doctor

David Holt

Billy (Age 17)

Virginia Gilmore

Myra Tinsley

Babe Ruth

Theodore Lorch

Neighbor Leaning Through Window (uncredited)

Anita Sharp-Bolster

Sasha's Mother (uncredited)

George Offerman, Jr.

Freshman (uncredited)

Walter Tetley

Cake Delivery Boy (uncredited)

Eddie Hall

Reporter in Hospital Room (uncredited)

John Sheehan

First Paper Hanger (uncredited)

George Guhl

Second Paper Hanger (uncredited)

Douglas Croft

Lou Gehrig as a Boy

Betty Brewer

Little Girl (uncredited)

Malcolm Waite

Big Strength Machine Contestant (uncredited)

Rosina Galli

Mrs. Fabrini (uncredited)

Edwin August

Restaurant Patron (uncredited)

Vaughan Glaser

Doctor in Gehrig Home (uncredited)

William Roy

Joe Fabrini (uncredited)

Jack Stewart

Ed Barrow (uncredited)

Patsy O'Byrne

Scrubwoman (uncredited)

Walter Fenner

Dentist (uncredited)

Elsa Janssen

Christina 'Mom' Gehrig

Janet Chapman

Tessie (uncredited)

Fay Holderness

Spectator (uncredited)

Wilmuth Merkyl

Spectator (uncredited)

Mitchell Ingraham

Barber (uncredited)

Veloz

Specialty Dancer (as Veloz and Yolanda)

Art Rowlands

Telephone Man (uncredited)

Bill Dickey

Ray Noble

Orchestra Leader (uncredited)

Yolanda

Specialty Dancer (as Veloz and Yolanda)

Bob Meusel

Robert W. Meusel (as Robert W. Meusel)

Mark Koenig

Bill Stern

Gene Collins

Billy (Age 8)

Ed Agresti

Barber (uncredited)

Ernie Alexander

Bellhop with Flowers (uncredited)

Bettye Avery

Nightclub Singer (uncredited)

Becky Bohanon

Little Girl (uncredited)

Roy Brent

Yankee Ballplayer (uncredited)

Jack Carr

Plumber (uncredited)

Burr Caruth

Village Storekeeper (uncredited)

Bill Chaney

Newsboy (uncredited)

Jack Chapin

Photographer (uncredited)

Porter Chase

Weight Guesser (uncredited)

Hal Cooke

Man in Cab (uncredited)

Eva Dennison

Mrs. Worthington (uncredited)

Peter Du Rey

Photographer in Hospital (uncredited)

Lorna Dunn

Clinic Nurse (uncredited)

Jim Farley

Spectator (uncredited)

Dick Gordon

Radio Listener (uncredited)

Herschel Graham

Spectator (uncredited)

Oscar 'Dutch' Hendrian

Furniture Mover (uncredited)

John Hiestand

Announcer (uncredited)

Charles Irwin

Carnival Batting Game Operator (uncredited)

Jack Irwin

Photographer in Hospital (uncredited)

Sheldon Jett

Sportsman at Ballgame (uncredited)

Payne B. Johnson

Boy in Ball Park (uncredited)

Richard Kipling

Broker (uncredited)

Pat Lane

Wheel of Chance Barker (uncredited)

Larry Lawson

Barker (uncredited)

Frank Lyman

Fraternity Boy (uncredited)

Dave Manley

Mayor Fiorello LaGuardia (uncredited)

Maurice Marks

Player (uncredited)

Francisco Marán

Rathskeller Headwaiter (uncredited)

John C. McCallum

Minor Role (uncredited)

Ralph McCullough

Reporter in Hospital (uncredited)

George McDonald

Wally Pipp (uncredited)

James McNamara

Rathskeller Manager (uncredited)

Irving Mitchell

Headwaiter (uncredited)

Pat Moriarity

Policeman in 1915 (uncredited)

John B. Old

Reporter (uncredited)

Tom Quinn

Reporter in Hospital (uncredited)

Henry Roquemore

Disappointed Fan #2 (uncredited)

Rip Russell

Laddie (uncredited)

Francis Sayles

Cab Driver (uncredited)

Jack Shea

Hammond (uncredited)

Brick Sullivan

Policeman (uncredited)

Jimmy Valentine

Sasha - Boy Playing Baseball (uncredited)

Gohr Van Vleck

Furniture Mover (uncredited)

Max Willenz

Mr. Colletti (uncredited)

Buddy Williams

Bootblack (uncredited)

Robert Winkler

Murphy (uncredited)

Allen Wood

Freshman (uncredited)

Mike Donovan

Charles Flynn

Fraternity Boy (uncredited)

Jack Gardner

Anthony Walters

Merril (uncredited)