Action Adventure Animation Comedy Family Sci-Fi
A white blood cell policeman, with the help of a cold pill, must stop a deadly virus from destroying the human they live in, Frank.
Directed by
Peter Farrelly, Bobby Farrelly
Written by
Marc Hyman
William Shatner
Mayor Phlegmming (voice)
Bill Murray
Frank Detorre
Laurence Fishburne
Thrax (voice)
Chris Rock
Osmosis Jones (voice)
Chris Elliott
Bob
Robert Wisdom
Big Germ (voice)
Brandy Norwood
Leah (voice)
Molly Shannon
Mrs. Boyd
David Hyde Pierce
Drix (voice)
Antonio Fargas
Chill the Flu Shot (voice)
Jonathan Adams
Officer Tom (voice)
Paul Pape
Male Red Blood Cell #2 (voice)
Carlos Alazraqui
Spanish Germ (voice)
Anne Lockhart
Female Red Blood Cell (voice)
Kid Rock
Kidney Rock (voice)
Rodger Bumpass
Joe Cramp / Announcer for Nerve News Network (voice)
Richard Steven Horvitz
Additional Character Voices (voice)
Zen Gesner
ER Doctor #1
Mickie McGowan
Brain Librarian (voice)
Danny Mann
Musician Cell (voice)
Donald Fullilove
Doughnut (voice)
Eddie Barth
Conductor (voice)
Rif Hutton
Charlie (voice)
Steve Susskind
Mob Boss Germ (voice)
Héctor Mercado
Additional Character Voices (voice)
Jackie Gonneau
Additional Character Voices (voice)
Paul Tuerpe
Additional Character Voices (voice)
Janis Dardaris
Additional Character Voices (voice)
Chris Phillips
Firefighter Doug (voice)
Nikki Tyler-Flynn
Nurse #2
Danny Murphy
Zookeeper Superintendent
Sally Brooks
Additional Character Voices (voice)
Sherry Lynn
Trudy (voice)
Kevin J. Flynn
Docky's Clamshack Waiter
Tom Sito
Elena Franklin
Shane Detorre
Herschel Sparber
Bruiser (voice)
Al Rodrigo
Frank Police Department Walkie Talkie (voice)
Doug Stone
Police Officer Jamie (voice)
Jackie Flynn
School Janitor
John Melendez
Artie (voice)
Abe Farrelly
Bus Girl #2
Keri Tombazian
Additional Character Voices (voice)
John-Eliot Jordan
Pea Soup Manager
Sean Gildea
Dreamy Photographer
Keith Anthony
Additional Character Voices (voice)
Michael Carven
Additional Character Voices (voice)
Paul Christie
Dan Matter / Germ (voice)
Wendy Dillon
Additional Character Voices (voice)
Eddie Frierson
Frank Police Department Officer (voice)
Shannon Gregory
Additional Character Voices (voice)
Art Kimbro
Additional Character Voices (voice)
Joyce Kurtz
Additional Character Voices (voice)
Kenny Olson
Kidney Rock Band (voice)
Jason Krause
Kidney Rock Band (voice)
Joe C.
Kidney Rock Band (voice)
Stefanie Eulinberg
Kidney Rock Band (voice)
Jimmie Bones
Kidney Rock Band (voice)
Uncle Kracker
Kidney Rock Band (voice)
David Ossman
Scabies (voice) (uncredited)
Marilyn Pasekoff
Additional Character Voices (voice)
Jack McCullough
Zookeeper
Will Dunn
Oyster Boy
Kelsey Jordan
Bus Girl #1
Jesse Peter
Laughing Boy
Nancy Byers
Pea Soup Supervisor
Kathryn Frick
Nurse #1
Elizabeth Jordan
Nurse #3
Diane Conrad
Zoo Visitor or Staff
Judith Conrad
Zoo Visitor or Staff
Erica Johnson
Zoo Visitor or Staff
Bo Cleary
Pea Soup Staff
Bruce McIntyre
Pea Soup Staff
Docky
The Bikini Gang
Joe Murphy
The Bikini Gang
Brian Mone
Police Officer
Sean Fitzgerald
Police Officer
Grace Costa
ER Nurse
Emily O’Donnell
School Girl
Mark Kausler

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