Family Comedy Action Adventure Fantasy
When a professor develops a vaccine that eliminates human allergies to dogs, he unwittingly upsets the fragile balance of power between cats and dogs and touches off an epic battle for pet supremacy. The fur flies as the feline faction, led by Mr. Tinkles, squares off against wide-eyed puppy Lou and his canine cohorts.
Directed by
Lawrence Guterman
Tobey Maguire
Lou the Beagle (voice)
Susan Sarandon
Ivy (voice)
Jeff Goldblum
Professor Brody
Alec Baldwin
Butch (voice)
Miriam Margolyes
Sophie the Castle Maid
Frank Welker
Buddy (voice)
Elizabeth Perkins
Mrs. Brody
Joe Pantoliano
Peek (voice)
Billy West
Ninja Cat #1 (voice)
Charlton Heston
The Mastiff (voice)
Michael Clarke Duncan
Sam (voice)
Sean Hayes
Mr. Tinkles (voice)
Jon Lovitz
Calico (voice)
John Michael Higgins
Ginger Kitten (voice)
Lauren K. Robek
Pie Mom (as Kirsten Robek)
Richard Steven Horvitz
Puppy in Barn (voice)
Danny Mann
Ninja Cat (voice)
Salome Jens
Collie at HQ (voice)
Gillian Barber
Factory Receptionist
Frank C. Turner
The Farmer
Alvin Sanders
Mason Employee
Brad Loree
Ken Kirzinger
Paul Pape
Wolf Blitzer (voice)
Carol Ann Susi
Sophie's Sister
Alexander Pollock
Scotty Brody
Myron Natwick
Mr. Mason
Mar Andersons
Guard at Gate
Pamela Perry
Yorkie Dog Owner
Mark Schooley
Mason Employee
Jovan Nenadic
Doris Chillcott
Mrs. Calvert
Peggy Logan
Nurse
Randi Kaplan
Sophie's Sister
Mary Bogue
Sophie's Sister
Babe Dolan
Wife Passenger
Charles Andre
Truck Driver
Alicia Michelle
Jogger
Victor Wilson
Doberman Drill Sergeant (voice)
David Mylrea

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