Family Comedy Action Adventure Fantasy
When a professor develops a vaccine that eliminates human allergies to dogs, he unwittingly upsets the fragile balance of power between cats and dogs and touches off an epic battle for pet supremacy. The fur flies as the feline faction, led by Mr. Tinkles, squares off against wide-eyed puppy Lou and his canine cohorts.
Directed by
Lawrence Guterman
Tobey Maguire
Lou the Beagle (voice)
Susan Sarandon
Ivy (voice)
Jeff Goldblum
Professor Brody
Frank Welker
Buddy (voice)
Alec Baldwin
Butch (voice)
Elizabeth Perkins
Mrs. Brody
Charlton Heston
The Mastiff (voice)
Joe Pantoliano
Peek (voice)
Michael Clarke Duncan
Sam (voice)
Jon Lovitz
Calico (voice)
Miriam Margolyes
Sophie the Castle Maid
Billy West
Ninja Cat #1 (voice)
Danny Mann
Ninja Cat (voice)
John Michael Higgins
Ginger Kitten (voice)
Sean Hayes
Mr. Tinkles (voice)
Frank C. Turner
The Farmer
Salome Jens
Collie at HQ (voice)
Lauren K. Robek
Pie Mom (as Kirsten Robek)
Ken Kirzinger
Gillian Barber
Factory Receptionist
Richard Steven Horvitz
Puppy in Barn (voice)
Carol Ann Susi
Sophie's Sister
Myron Natwick
Mr. Mason
Brad Loree
Alvin Sanders
Mason Employee
Paul Pape
Wolf Blitzer (voice)
Alexander Pollock
Scotty Brody
Pamela Perry
Yorkie Dog Owner
Jovan Nenadic
Mar Andersons
Guard at Gate
Mark Schooley
Mason Employee
Doris Chillcott
Mrs. Calvert
Peggy Logan
Nurse
Randi Kaplan
Sophie's Sister
Mary Bogue
Sophie's Sister
Babe Dolan
Wife Passenger
Charles Andre
Truck Driver
Alicia Michelle
Jogger
Victor Wilson
Doberman Drill Sergeant (voice)
David Mylrea

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