Family Comedy Action Adventure Fantasy
When a professor develops a vaccine that eliminates human allergies to dogs, he unwittingly upsets the fragile balance of power between cats and dogs and touches off an epic battle for pet supremacy. The fur flies as the feline faction, led by Mr. Tinkles, squares off against wide-eyed puppy Lou and his canine cohorts.
Directed by
Lawrence Guterman
Tobey Maguire
Lou the Beagle (voice)
Jeff Goldblum
Professor Brody
Alec Baldwin
Butch (voice)
Michael Clarke Duncan
Sam (voice)
Susan Sarandon
Ivy (voice)
Frank Welker
Buddy (voice)
Joe Pantoliano
Peek (voice)
Miriam Margolyes
Sophie the Castle Maid
Elizabeth Perkins
Mrs. Brody
Charlton Heston
The Mastiff (voice)
Sean Hayes
Mr. Tinkles (voice)
Gillian Barber
Factory Receptionist
Jon Lovitz
Calico (voice)
Richard Steven Horvitz
Puppy in Barn (voice)
Billy West
Ninja Cat #1 (voice)
John Michael Higgins
Ginger Kitten (voice)
Pamela Perry
Yorkie Dog Owner
Salome Jens
Collie at HQ (voice)
Danny Mann
Ninja Cat (voice)
Paul Pape
Wolf Blitzer (voice)
Carol Ann Susi
Sophie's Sister
Charles Andre
Truck Driver
Lauren K. Robek
Pie Mom (as Kirsten Robek)
Brad Loree
Frank C. Turner
The Farmer
Alvin Sanders
Mason Employee
Ken Kirzinger
Mark Schooley
Mason Employee
Myron Natwick
Mr. Mason
Mar Andersons
Guard at Gate
Alexander Pollock
Scotty Brody
Frank Meschkuleit
Additional Performances (puppeteer)
Peggy Logan
Nurse
Doris Chillcott
Mrs. Calvert
Jovan Nenadic
Randi Kaplan
Sophie's Sister
Mary Bogue
Sophie's Sister
Babe Dolan
Wife Passenger
Alicia Michelle
Jogger
Victor Wilson
Doberman Drill Sergeant (voice)
David Mylrea

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